Therapy of Diabetes Mellitus Using Experimental Animal Models
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چکیده
منابع مشابه
Therapy of Diabetes Mellitus Using Experimental Animal Models*
Diabetes mellitus is a worldwide epidemic with high mortality. As concern over this disease rises, the number and value of research grants awarded by the National Research Foundation of Korea (NRF) have increased. Diabetes mellitus is classified into two groups. Type 1 diabetes requires insulin treatment, whereas type 2 diabetes, which is characterized by insulin resistance, can be treated usin...
متن کاملExperimental Diabetes Mellitus in Different Animal Models
Animal models have historically played a critical role in the exploration and characterization of disease pathophysiology and target identification and in the evaluation of novel therapeutic agents and treatments in vivo. Diabetes mellitus disease, commonly known as diabetes, is a group of metabolic disorders characterized by high blood glucose levels for a prolonged time. To avoid late complic...
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Diabetes mellitus is a heterogeneous group of chronic disorders of carbohydrate, lipid and protein metabolism characterized by high blood glucose levels due to relative or absolute deficiency of insulin (Eiselein et al., 2004). Hyperglycemia, the primary clinical manifestation of diabetes, is associated with the development of diabetic complications. Several studies have suggested that hypergly...
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Type 2 diabetes mellitus (DM2) is the most common chronic metabolic disease, affecting approximately 6% of the adult population in the Western world. This condition is a major cause of cardiovascular disease, blindness, renal failure, and amputations, with increasing prevalence worldwide. The influence of obesity on type 2 diabetes risk is determined by the degree of obesity and by body fat loc...
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Due to current improvements in techniques for islet isolation and transplantation and protocols for immunosuppressants, islet transplantation has become an effective treatment for severe diabetes patients. Many diabetic animal models have contributed to such improvements. In this paper, we focus on 3 types of models with different mechanisms for inducing diabetes mellitus (DM): models induced b...
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ژورنال
عنوان ژورنال: Asian-Australasian Journal of Animal Sciences
سال: 2010
ISSN: 1011-2367,1976-5517
DOI: 10.5713/ajas.2010.90637